Content Contributor: Ryan P. Smith, MD and Christine Hill-Kayser, MD Show
Last Reviewed: April 5, 2022 What is staging for cancer?Staging is the process of learning how much cancer is in your body and where it is. For laryngeal cancer, tests like laryngoscopy, endoscopy, fine needle aspiration, barium swallow (if you are having trouble swallowing), CT, MRI, and/or PET scans may be done to help stage your cancer. Your providers need to know about your cancer and your health so that they can plan the best treatment for you. Staging looks at the size of the tumor and where it is, and if it has spread to other organs. The staging system for laryngeal cancer is called the “TNM system,” as described by the American Joint Committee on Cancer. It has three parts:
Your healthcare provider will use the results of the tests you had to determine your TNM result and combine these to get a stage from 0 to IV. How is laryngeal cancer staged?Laryngeal cancer impacts the voice box and the epiglottis. The staging of laryngeal cancer is based on where in the larynx the cancer starts. There are three parts of the larynx:
Staging for laryngeal cancer is based on:
Staging is important because it helps to guide your treatment options. The staging system is very complex. Below is a summary staging system. Talk to your provider about the stage of your cancer.
How is laryngeal cancer treated?Treatment for laryngeal cancer depends on the location of your cancer and if it has spread. Your treatment may include some or all of the following:
SurgeryThe goal of surgery is to remove all of or as much of the cancer as possible while and not damage other tissue or organs near the tumor. There are a number of surgical options to treat cancer of the larynx. Possible surgical treatments for laryngeal cancer include:
If the cancer has grown into your throat, you may have a partial or full pharyngectomy, which is the removal of the throat. If the cancer has affected your thyroid, you may need a thyroidectomy. (will link to these) After any surgery for laryngeal cancer you may require more treatment to help you recover. This includes:
Radiation TherapyYou may need radiation therapy. Radiation therapy uses high-energy x-rays to kill cancer cells. Radiation may be used as the only treatment or in combination with surgery and/or chemotherapy. Early-stage laryngeal cancer may be treated with radiation alone. This can preserve better voice quality for some patients. When radiation is used with surgery it is called adjuvant therapy. Radiation may be used after surgery to kill any remaining cancer cells and to lower the chance of recurrence (your cancer coming back). Radiation may also be used for patients who cannot have surgery or whose cancer is so advanced that the goal is to manage symptoms, such as pain and bleeding. It can result in side effects such as skin irritation and it can affect nearby glands and tissues. ChemotherapyChemotherapy is the use of anti-cancer medicines that go through your whole body. These medicines may be given through a vein (IV, intravenously) or by mouth. Chemotherapy is used to treat laryngeal cancer if it has spread (metastasized) or if the cancer was not completely removed during surgery. The chemotherapy medications commonly used to treat laryngeal cancer include cisplatin, carboplatin, fluorouracil, docetaxel, paclitaxel, methotrexate, capecitabine and epirubicin. Cetuximab, a targeted therapy, can be used in combination with chemotherapy or radiation to treat laryngeal cancer. Immunotherapy is the use of a person's own immune system to kill cancer cells. Pembrolizumab and nivolumab are both immunotherapy medications that target and block PD-1. PD-1 is a protein and when it is blocked the body starts an immune response against the cancer cells, which shrinks or slows tumor growth. These medications may be used for the recurrence of the cancer. In some cases, pembrolizumab is the first type of treatment used. Chemotherapy and radiation can be used together. This is called chemoradiation. Medications used in chemoradiation include carboplatin, cisplatin, docetaxel and/or cetuximab. Your oncology team will go over the options and chose the best chemotherapy plan with you. Clinical TrialsYou may be offered a clinical trial as part of your treatment plan. To find out more about current clinical trials, visit the OncoLink Clinical Trials Matching Service. Making Treatment DecisionsYour care team will make sure you are included in choosing your treatment plan. This can be overwhelming as you may be given a few options to choose from. It feels like an emergency, but you can take a few weeks to meet with different providers and think about your options and what is best for you. This is a personal decision. Friends and family can help you talk through the options and the pros and cons of each, but they cannot make the decision for you. You need to be comfortable with your decision – this will help you move on to the next steps. If you ever have any questions or concerns, be sure to call your team. You can learn more about laryngeal cancer at Oncolink.org ReferencesAmerican Cancer Society: Laryngeal and Hypopharyngeal Cancer. 2017. Found at: http://www.cancer.org/cancer/laryngealandhypopharyngealcancer American Joint Committee on Cancer (AJCC) TNM Staging System for the Larynx (8th ed.) Connor et al. Treatment, comorbidity and survival in stage III laryngeal cancer. Head and Neck. 2015:37(5)698-706. Misono S. et al. Treatment and Survival in 10,429 patients with localized laryngeal cancer: a population-based analysis. Cancer. 2014:1810-1817. National Cancer Institute Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: Larynx Cancer. Found at: http://seer.cancer.gov/statfacts/html/laryn.html National Institute of Health. National Cancer Institute: Laryngeal Cancer Treatment (PDQ®) Updated May 19, 2019. Found at: https://www.cancer.gov/types/head-and-neck/patient/adult/laryngeal-treatment-pdq Which surgical procedure for neck cancer leads to the absence of a natural voice?A laryngectomy is surgical removal of the larynx, also called the voice box.
Which pain related clinical manifestation would the nurse expect in a client who had received a diagnosis of peptic ulcer disease?Patients may describe the pain of peptic ulcer as burning or gnawing, or as hunger pains slowly building up for 1–2 hours, then gradually decreasing. Use of antacids may provide temporary relief. Classically, gastric ulcer pain is aggravated by meals, whereas the pain of duodenal ulcers is relieved by meals.
Which substance will the home care nurse instruct a client to use after a laryngectomy to cleanse the stoma site?Which substance will the home care nurse instruct a client to use after laryngectomy to cleanse the stoma site? Mild soap and water are used to cleanse the stoma site. Sterile saline, a humidifier, or pans of water can be used to humidify the air entering the stoma.
Which assessment finding of a client being treated in the emergency department after a motor vehicle collision indicates the need for immediate?Which assessment finding of a client being treated in the emergency department after a motor vehicle collision indicates the need for immediate health care provider intervention? Facial edema and septal deviation indicate that the client has sustained facial injuries.
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