General Genetic Implications: Pronunciation: Trade Name(s) Ther. Class. antihypertensives Pharm. Class. beta blockers Action Therapeutic Effect(s): Absorption: Well absorbed but rapidly undergoes extensive first-pass hepatic metabolism, resulting in 25–35% bioavailability. Food slows absorption. Distribution: Unknown. Protein Binding: 98%. Metabolism and Excretion: Extensively metabolized (primarily by CYP2D6 and CYP2C9; the CYP2D6 enzyme system exhibits genetic polymorphism);
~7% of population may be poor metabolizers and may have significantly ↑ carvedilol concentrations and an ↑ risk of adverse effects); excreted in feces via bile, <2% excreted unchanged in urine. Half-life: 7–10 hr. TIME/ACTION PROFILE (cardiovascular effects)
Contraindication/PrecautionsContraindicated in:
Use Cautiously in:
Adverse Reactions/Side EffectsCV: BRADYCARDIA, HF, PULMONARY EDEMA Derm: STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, itching, rashes, urticaria EENT: blurred vision, dry eyes, intraoperative floppy iris syndrome, nasal stuffiness Endo: hyperglycemia, hypoglycemia GI: diarrhea, constipation, nausea GU: erectile dysfunction, ↓ libido MS: arthralgia, back pain, muscle cramps Neuro: paresthesia, dizziness, fatigue, weakness, anxiety, depression, drowsiness, insomnia, memory loss, mental status changes, nervousness, nightmares Resp: bronchospasm, wheezing Misc: HYPERSENSITIVITY REACTIONS (including anaphylaxis and angioedema), drug-induced lupus syndrome * CAPITALS indicate life-threatening. InteractionsDrug-Drug
Route/DosagePO (Adults): Hypertension– 6.25 mg twice daily, may be ↑ every 7–14 days up to 25 mg twice daily or extended-release– 20 mg once daily, dose may be doubled every 7–14 days up to 80 mg once daily; HF– 3.125 mg twice daily for 2 wk; may be ↑ to 6.25 mg twice daily. Dose may be doubled every 2 wk as tolerated (not to exceed 25 mg twice daily in patients <85 kg or 50 mg twice daily in patients >85 kg) or extended-release– 10 mg once daily, dose may be doubled every 2 wk as tolerated up to 80 mg once daily; Left ventricular dysfunction after MI– 6.25 mg twice daily, ↑ after 3–10 days to 12.5 twice daily then to target dose of 25 mg twice daily; some patients may require lower initial doses and slower titration or extended-release– 20 mg once daily, dose may be doubled every 3–10 days up to 80 mg once daily. Availability (generic available)Extended-release capsules: 10 mg, 20 mg, 40 mg, 80 mg Cost: all strengths $175.36/30 Tablets: 3.125 mg, 6.25 mg, 12.5 mg, 25 mg Cost: Generic: All strengths $7.18/100 Assessment
Lab Test Considerations: May cause ↑ BUN, serum lipoprotein, potassium, triglyceride, and uric acid levels.
Toxicity and Overdose: Monitor patients receiving beta blockers for signs of overdose (bradycardia, severe dizziness or fainting, severe drowsiness, dyspnea, bluish fingernails or palms, seizures). Notify health care professional immediately if these signs occur. Potential Diagnoses
Implementation
Patient/Family Teaching
Evaluation/Desired Outcomes
carvedilol is a sample topic from the Davis's Drug Guide. To view other topics, please log in or purchase a subscription. Nursing Central is an award-winning, complete mobile solution for nurses and students. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Complete Product Information. What condition would alert the nurse of need to use beta adrenergic blockers cautiously?Nursing Considerations: Nonselective beta blockers must be used cautiously with patients who have co-existing asthma or chronic obstructive pulmonary disease (COPD) because of the effects on Beta-2 receptors that could potentially cause bronchoconstriction.
Which condition is an absolute contraindication to taking beta blockers?CONTRAINDICATIONS TO BETA BLOCKERS
Beta blockers should not be administered to patients with heart failure who have bradycardia, heart block or hemodynamic instability.
What health teaching should the nurse provide for the client receiving beta blockers?Because beta blockers lower the heart rate and blood pressure, you will need to monitor your patient for bradycardia and hypotension, including orthostatic hypotension. With that said, always get a blood pressure and heart rate prior to giving the dose.
Which cholinergic symptoms of Parkinson's disease are reduced with anticholinergic drugs?Anticholinergic Medications: Anticholinergic medications are used to treat tremor and dystonia in people with Parkinson's. They do this by reducing the amount of acetylcholine, a neurotransmitter that is in balance with dopamine in the body.
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