• Diagnostic criteria include multiple cognitive deficits that develop gradually and steadily
• Predominant are impairment of memory, orientation, judgement, and reasoning
• Inability to integrate new information results in failure to learn new associations
• Individuals tend to lost interest in others, and as a result become more socially isolated
• As the disorder progresses, they can become agitated, confused, depressed, anxious, or even more combative
○ "sundowner syndrome"
• People also display one or more neurocognitive disorders including aphasia (difficulty with language), apraxia (impaired motor functioning), agnosia (failure to recognize objects), or difficulty with activities such as planning, organizing, sequencing, or abstracting information
• In the past, definitive diagnosis of Alzheimer's disease could be made only after an autopsy determined that certain characteristic types of damage were present in the brain
• Growing evidence that the use of sophisticated brain scan along with new chemical tracers may soon be able to help clinicians identify the presence of Alzheimer's before significant declines on cognitive abilities (Alzheimer's disease Neuroimaging Initiative (ADNI))
• Markers include : beta amyloid found in spinal fluid appears to increase the accuracy of diagnosis
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